Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3843691..3844327 Replicon chromosome
Accession NZ_CP121861
Organism Bacillus stercoris strain Mal05

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QA442_RS19940 Protein ID WP_003156187.1
Coordinates 3843691..3844041 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QA442_RS19945 Protein ID WP_003225183.1
Coordinates 3844046..3844327 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA442_RS19900 (3838735) 3838735..3839334 - 600 WP_040084112.1 phosphoserine phosphatase RsbX -
QA442_RS19905 (3839334) 3839334..3840122 - 789 WP_014662857.1 RNA polymerase sigma factor SigB -
QA442_RS19910 (3840088) 3840088..3840570 - 483 WP_014662856.1 anti-sigma B factor RsbW -
QA442_RS19915 (3840567) 3840567..3840896 - 330 WP_095432086.1 anti-sigma factor antagonist RsbV -
QA442_RS19920 (3840958) 3840958..3841965 - 1008 WP_095432087.1 phosphoserine phosphatase RsbU -
QA442_RS19925 (3841977) 3841977..3842378 - 402 WP_003240352.1 serine/threonine-protein kinase RsbT -
QA442_RS19930 (3842382) 3842382..3842747 - 366 WP_003225190.1 RsbT antagonist protein RsbS -
QA442_RS19935 (3842752) 3842752..3843576 - 825 WP_095432088.1 RsbT co-antagonist protein RsbRA -
QA442_RS19940 (3843691) 3843691..3844041 - 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QA442_RS19945 (3844046) 3844046..3844327 - 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QA442_RS19950 (3844443) 3844443..3845612 - 1170 WP_095432089.1 alanine racemase -
QA442_RS19955 (3845727) 3845727..3846743 - 1017 WP_003234282.1 outer membrane lipoprotein carrier protein LolA -
QA442_RS19960 (3846909) 3846909..3847274 - 366 WP_069839917.1 holo-ACP synthase -
QA442_RS19965 (3847369) 3847369..3847968 + 600 WP_095432090.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T276600 WP_003156187.1 NZ_CP121861:c3844041-3843691 [Bacillus stercoris]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT276600 WP_003225183.1 NZ_CP121861:c3844327-3844046 [Bacillus stercoris]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References