Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1378501..1380074 Replicon chromosome
Accession NZ_CP121859
Organism Aeromonas veronii strain LOID 15995

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS25_RS06735 Protein ID WP_274161032.1
Coordinates 1378755..1380074 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS25_RS06730 Protein ID WP_017410478.1
Coordinates 1378501..1378755 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS25_RS06710 1373972..1375333 + 1362 WP_274161030.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
QBS25_RS06715 1375496..1376635 + 1140 WP_274161031.1 site-specific integrase -
QBS25_RS06720 1377460..1377909 + 450 WP_160836704.1 nucleotidyltransferase domain-containing protein -
QBS25_RS06725 1378146..1378331 + 186 WP_279498895.1 DUF86 domain-containing protein -
QBS25_RS06730 1378501..1378755 + 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
QBS25_RS06735 1378755..1380074 + 1320 WP_274161032.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS25_RS06740 1380495..1382477 - 1983 WP_274161033.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
QBS25_RS06745 1382474..1383358 - 885 WP_274161046.1 ABC transporter substrate-binding protein -
QBS25_RS06750 1383394..1384158 - 765 WP_151286442.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49615.56 Da        Isoelectric Point: 6.6626

>T276589 WP_274161032.1 NZ_CP121859:1378755-1380074 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDETYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT276589 WP_017410478.1 NZ_CP121859:1378501-1378755 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References