Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4376439..4378012 Replicon chromosome
Accession NZ_CP121856
Organism Aeromonas veronii strain LOID 16013

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS18_RS20565 Protein ID WP_274161032.1
Coordinates 4376439..4377758 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS18_RS20570 Protein ID WP_017410478.1
Coordinates 4377758..4378012 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS18_RS20550 4372355..4373119 + 765 WP_151286442.1 ATP-binding cassette domain-containing protein -
QBS18_RS20555 4373154..4374038 + 885 WP_274161046.1 ABC transporter substrate-binding protein -
QBS18_RS20560 4374035..4376017 + 1983 WP_274161033.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
QBS18_RS20565 4376439..4377758 - 1320 WP_274161032.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS18_RS20570 4377758..4378012 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
QBS18_RS20575 4378182..4378367 - 186 WP_279498895.1 DUF86 domain-containing protein -
QBS18_RS20580 4378604..4379053 - 450 WP_160836704.1 nucleotidyltransferase domain-containing protein -
QBS18_RS20585 4379878..4381017 - 1140 WP_274161031.1 site-specific integrase -
QBS18_RS20590 4381180..4382541 - 1362 WP_274161030.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49615.56 Da        Isoelectric Point: 6.6626

>T276588 WP_274161032.1 NZ_CP121856:c4377758-4376439 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDETYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT276588 WP_017410478.1 NZ_CP121856:c4378012-4377758 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References