Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3588614..3590187 Replicon chromosome
Accession NZ_CP121833
Organism Aeromonas veronii strain ANYA 18644

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS23_RS16780 Protein ID WP_279500377.1
Coordinates 3588614..3589933 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS23_RS16785 Protein ID WP_017410478.1
Coordinates 3589933..3590187 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS23_RS16765 3584521..3585285 + 765 WP_279500373.1 ATP-binding cassette domain-containing protein -
QBS23_RS16770 3585320..3586213 + 894 WP_279502959.1 ABC transporter substrate-binding protein -
QBS23_RS16775 3586210..3588192 + 1983 WP_279500375.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
QBS23_RS16780 3588614..3589933 - 1320 WP_279500377.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS23_RS16785 3589933..3590187 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
QBS23_RS16790 3590357..3590785 - 429 WP_279500379.1 DUF86 domain-containing protein -
QBS23_RS16795 3590944..3592122 - 1179 Protein_3241 IS3 family transposase -
QBS23_RS16800 3592740..3593357 + 618 WP_107683433.1 recombinase family protein -
QBS23_RS16805 3593354..3593677 - 324 WP_021231525.1 hypothetical protein -
QBS23_RS16810 3594210..3594374 + 165 WP_279500382.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3590800..3592149 1349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49578.59 Da        Isoelectric Point: 7.0590

>T276585 WP_279500377.1 NZ_CP121833:c3589933-3588614 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIARAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT276585 WP_017410478.1 NZ_CP121833:c3590187-3589933 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References