Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4322809..4324382 Replicon chromosome
Accession NZ_CP121817
Organism Aeromonas veronii strain ANYA 19170

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS21_RS20335 Protein ID WP_201915019.1
Coordinates 4322809..4324128 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS21_RS20340 Protein ID WP_017410478.1
Coordinates 4324128..4324382 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS21_RS20320 4318724..4319488 + 765 WP_107683436.1 ATP-binding cassette domain-containing protein -
QBS21_RS20325 4319523..4320407 + 885 WP_107683435.1 ABC transporter substrate-binding protein -
QBS21_RS20330 4320404..4322387 + 1984 Protein_3914 Fe(3+)-hydroxamate ABC transporter permease FhuB -
QBS21_RS20335 4322809..4324128 - 1320 WP_201915019.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS21_RS20340 4324128..4324382 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
QBS21_RS20345 4325078..4326091 - 1014 WP_000845039.1 class 1 integron integrase IntI1 -
QBS21_RS20350 4326236..4326733 + 498 WP_001083725.1 trimethoprim-resistant dihydrofolate reductase DfrA12 -
QBS21_RS20355 4326921..4327136 + 216 WP_247754197.1 DUF1010 domain-containing protein -
QBS21_RS20360 4327142..4327980 + 839 Protein_3920 AadA family aminoglycoside 3''-O-nucleotidyltransferase -
QBS21_RS20365 4328097..4328445 + 349 Protein_3921 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
QBS21_RS20370 4328439..4329278 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island dfrA12 / aadA2 / mph(A) / tet(A) / floR - 4322809..4360135 37326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49566.54 Da        Isoelectric Point: 6.8810

>T276584 WP_201915019.1 NZ_CP121817:c4324128-4322809 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGTHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT276584 WP_017410478.1 NZ_CP121817:c4324382-4324128 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References