Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 901237..902810 Replicon chromosome
Accession NZ_CP121816
Organism Aeromonas veronii strain ANYA 19953

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS33_RS04355 Protein ID WP_279497196.1
Coordinates 901237..902556 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3Q8DTG9
Locus tag QBS33_RS04360 Protein ID WP_042047685.1
Coordinates 902556..902810 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS33_RS04340 897155..897919 + 765 WP_279497194.1 ATP-binding cassette domain-containing protein -
QBS33_RS04345 897953..898837 + 885 WP_279497736.1 ABC transporter substrate-binding protein -
QBS33_RS04350 898834..900816 + 1983 WP_279497195.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
QBS33_RS04355 901237..902556 - 1320 WP_279497196.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS33_RS04360 902556..902810 - 255 WP_042047685.1 helix-turn-helix domain-containing protein Antitoxin
QBS33_RS04365 903348..903965 + 618 WP_279497197.1 recombinase family protein -
QBS33_RS04370 903962..904285 - 324 WP_279497198.1 hypothetical protein -
QBS33_RS04375 904865..906652 + 1788 WP_103255138.1 P-loop NTPase fold protein -
QBS33_RS04380 906652..907404 + 753 WP_279497199.1 hypothetical protein -
QBS33_RS04385 907401..907724 + 324 WP_279497200.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49692.71 Da        Isoelectric Point: 6.5920

>T276583 WP_279497196.1 NZ_CP121816:c902556-901237 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYRESWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNMEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGTGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT276583 WP_042047685.1 NZ_CP121816:c902810-902556 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DTG9

References