Detailed information of TA system TA276582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 2468961..2470675
• Replicon: chromosome
• Accession: NZ_CP121802
• Organism: Aeromonas dhakensis strain BOND 14504

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: -
• Locus tag: QBS10_RS11830
• Protein ID: WP_279450343.1
• Coordinates: 2468961..2469614 (+)
• Length: 218 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: QBS10_RS11835
• Protein ID: WP_279450344.1
• Coordinates: 2469611..2470675 (+)
• Length: 355 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QBS10_RS11810	2463985..2464173	+	189	WP_021138010.1	DUF3283 family protein	-
QBS10_RS11815	2464320..2464718	+	399	WP_279450339.1	hypothetical protein	-
QBS10_RS11820	2464904..2467354	+	2451	WP_279450340.1	type I restriction-modification system subunit M	-
QBS10_RS11825	2467351..2468694	+	1344	WP_279450341.1	restriction endonuclease subunit S	-
QBS10_RS11830	2468961..2469614	+	654	WP_279450343.1	DUF4433 domain-containing protein	Toxin
QBS10_RS11835	2469611..2470675	+	1065	WP_279450344.1	macro domain-containing protein	Antitoxin
QBS10_RS11840	2470750..2473881	+	3132	WP_279450345.1	HsdR family type I site-specific deoxyribonuclease	-
QBS10_RS11845	2473881..2474606	+	726	WP_279450346.1	SprT family zinc-dependent metalloprotease	-
QBS10_RS11850	2474614..2475552	-	939	WP_171269279.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2450413..2474606	24193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (17-216)

Antitoxin

• Macro domain (18-131)

Sequences

Toxin

Protein

• Length: 218 a.a.
• Molecular weight: 25459.07 Da
• Isoelectric Point: 6.6560

>T276582 WP_279450343.1 NZ_CP121802:2468961-2469614 [Aeromonas dhakensis]
MAYDYSQSLNPEKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLVPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRENDEILILVSSLHRMAELGLPFVFTDSHAYYQWANFYVDLGDLERIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNRVEQCMNRVGVARPVYVRDGWYFR

Nucleotide

• Length: 654 bp

Antitoxin

Protein

• Length: 355 a.a.
• Molecular weight: 39602.73 Da
• Isoelectric Point: 6.5007

>AT276582 WP_279450344.1 NZ_CP121802:2469611-2470675 [Aeromonas dhakensis]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQEGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSSQYQNVAKRGG
VAELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTLSALREGL
HRWPAGTPWGERKARLFDDRSLQIALTRLQQGLV

Nucleotide

• Length: 1065 bp