Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2437291..2438884 Replicon chromosome
Accession NZ_CP121801
Organism Aeromonas dhakensis strain BOND 19077

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS22_RS11560 Protein ID WP_279484089.1
Coordinates 2437291..2438607 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS22_RS11565 Protein ID WP_279484090.1
Coordinates 2438591..2438884 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS22_RS11535 2432667..2433821 - 1155 WP_279484086.1 ElyC/SanA/YdcF family protein -
QBS22_RS11540 2434304..2435515 + 1212 WP_211028522.1 NupC/NupG family nucleoside CNT transporter -
QBS22_RS11545 2435697..2436140 + 444 WP_279484087.1 inhibitor of vertebrate lysozyme family protein -
QBS22_RS11550 2436210..2436752 - 543 WP_279484088.1 beta/gamma crystallin-related protein -
QBS22_RS11555 2436950..2437192 - 243 WP_005302916.1 DUF3297 family protein -
QBS22_RS11560 2437291..2438607 - 1317 WP_279484089.1 HipA domain-containing protein Toxin
QBS22_RS11565 2438591..2438884 - 294 WP_279484090.1 helix-turn-helix domain-containing protein Antitoxin
QBS22_RS11570 2439165..2439692 + 528 WP_279484091.1 metal-dependent hydrolase -
QBS22_RS11575 2439842..2440567 - 726 WP_279484092.1 hypothetical protein -
QBS22_RS11580 2440592..2441923 - 1332 WP_279484093.1 ATP-binding protein -
QBS22_RS11585 2443062..2443868 - 807 WP_279484094.1 tryptophan synthase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-390)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49597.67 Da        Isoelectric Point: 6.0490

>T276580 WP_279484089.1 NZ_CP121801:c2438607-2437291 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLIKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVERRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

>T276580 NZ_CP121801:c2438607-2437291 [Aeromonas dhakensis]
ATGATGAATGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAATCAGCTGATCGGCCATCTCGAATATGACTCCAA
CCGGGATTCGTTTCAGCTCGGCTATCTGCCAGAGTGGCAAGCGCGCGGATTCCCACTCTCACCGCCACTGGCGTTGGATG
GCTCGGCCAGCAGCGCTCAGATCCGGGCGTATCTCGGCAACTTACTGCCAGAAAATCGCGGGCTGGATCATCTGATTGAG
GTACTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTGATCCACGGTATCGGCCGCGATGTATCCGGGGCTGTCACCTTCAC
CCTACCCGCAGAGCCCGACATTCCCACCCGGTTTCGCCCCATCACACCAGAGGAGTTGATGCTGCGCCTCGATCAACCCG
AGATTTGGCCGCTGGAAGTCTGGGATGGCCGCCCCCGACTCTCGGTTGCGGGTGTGCAGGCCAAACTCAACCTGCTGCGA
CTCGAGGGGAGGCTAGGATTTGGCGAAGGTGAACTCTGTTCAACCCACCTCATCAAGTTCGAGCATCACCCTCATCTGGT
GATCAATGAATTTGTAACCATGCAGCTGGCCGCACAGCTTAGCATGCCGGTGGCGCGGGTCGAACTGCATACTGTGGGTC
AGGGTGAGAAGTCCCACAGAAGCTTGCTGGTGGAACGGTTCGACCGTCGTCTTGATGAGGATGGCATGAGGGTCCGCCGT
CGCCACATGATCGATGCCTGTCAGGGGCTGGGGTTCCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGATGGTCGGGA
CGTGGCCCATATTCGGGAAGGGGTGAGCCTGCCACGGCTGTTCAGCCTTAGCGCTCTCTGCGTCAATCCAGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAATCACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGACGCCCACCCCTTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAACCAGCATCT
GGCCATGGCCATAGGCGACGAATTTGCTCCCGAGGCGATCAACGCATGGCAGTTGCTGGAAATGGCCGAGGCATGTGACC
TGCCCGAACGCCTGCTGCAACAGACCTTGCAGAAGATAGCCAGCGACATCCTCCACCATTTGGATGCCGCTATAGCCATG
GTCGAGACAGACCATCCCGCCGAGCTGGATTATCTGGCACGCTATAAAGATGACGTTGAGCGCCGTTGCCACCATTTTCA
GGAGCAGGCGGGGCTGTTGCCCGAACTGCAGCTATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10522.19 Da        Isoelectric Point: 6.2983

>AT276580 WP_279484090.1 NZ_CP121801:c2438884-2438591 [Aeromonas dhakensis]
MADTPLPTGLKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVTSSYSQPEVGDDEWF

Download         Length: 294 bp

>AT276580 NZ_CP121801:c2438884-2438591 [Aeromonas dhakensis]
ATGGCAGATACACCGTTGCCAACCGGCCTGAAAGAACTGGATCCCGCCTCGCTGGGACTGGCGATACGAGAGAGACGCAA
AGCAGCCAAGATGACCCAAGAGGTGACTGCCTCACTGTGTGGCATCTCCAAGAAGACCCTGATCAAGATTGAAAAAGGGG
GGGATGTCTACCTCTCGACCCTGCTGCAGGTGATGAAGGCGCTGGGACTGAGGTTGCAACTGGTGCAGGAAGCGGGATCA
CAGGTAACGAGCAGCTACAGCCAACCAGAGGTCGGTGATGATGAATGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References