Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2428321..2429885 Replicon chromosome
Accession NZ_CP121800
Organism Aeromonas dhakensis strain DAMIAN 19342

Toxin (Protein)


Gene name hipA Uniprot ID A0A2S4TP05
Locus tag QBS35_RS10960 Protein ID WP_005329232.1
Coordinates 2428575..2429885 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS35_RS10955 Protein ID WP_005329233.1
Coordinates 2428321..2428575 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS35_RS10930 2423896..2424474 - 579 WP_021140685.1 hypothetical protein -
QBS35_RS10935 2424806..2425258 - 453 WP_021140686.1 DUF2384 domain-containing protein -
QBS35_RS10940 2425513..2426820 + 1308 WP_021140687.1 Fic family protein -
QBS35_RS10945 2426899..2427150 + 252 WP_010674977.1 plasmid stabilization protein -
QBS35_RS10950 2427571..2427819 - 249 WP_010674978.1 hypothetical protein -
QBS35_RS10955 2428321..2428575 + 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
QBS35_RS10960 2428575..2429885 + 1311 WP_005329232.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS35_RS10970 2431110..2431532 - 423 WP_155292465.1 hypothetical protein -
QBS35_RS10975 2431543..2434191 - 2649 WP_080689759.1 peptidoglycan DD-metalloendopeptidase family protein -
QBS35_RS10980 2434204..2434602 - 399 WP_155292464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49096.31 Da        Isoelectric Point: 7.1717

>T276579 WP_005329232.1 NZ_CP121800:2428575-2429885 [Aeromonas dhakensis]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT276579 WP_005329233.1 NZ_CP121800:2428321-2428575 [Aeromonas dhakensis]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4TP05

Antitoxin

Source ID Structure

References