Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1098634..1100227 Replicon chromosome
Accession NZ_CP121800
Organism Aeromonas dhakensis strain DAMIAN 19342

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS35_RS05225 Protein ID WP_103828447.1
Coordinates 1098634..1099950 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS35_RS05230 Protein ID WP_041202615.1
Coordinates 1099934..1100227 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS35_RS05200 1094007..1095161 - 1155 WP_201882251.1 YdcF family protein -
QBS35_RS05205 1095646..1096857 + 1212 WP_017765670.1 NupC/NupG family nucleoside CNT transporter -
QBS35_RS05210 1097040..1097483 + 444 WP_043159737.1 inhibitor of vertebrate lysozyme family protein -
QBS35_RS05215 1097553..1098095 - 543 WP_043169783.1 beta/gamma crystallin-related protein -
QBS35_RS05220 1098293..1098535 - 243 WP_279464968.1 DUF3297 family protein -
QBS35_RS05225 1098634..1099950 - 1317 WP_103828447.1 HipA domain-containing protein Toxin
QBS35_RS05230 1099934..1100227 - 294 WP_041202615.1 helix-turn-helix domain-containing protein Antitoxin
QBS35_RS05235 1100508..1101050 + 543 WP_043169781.1 metal-dependent hydrolase -
QBS35_RS05240 1101625..1102605 - 981 WP_279464820.1 IS5-like element IS5 family transposase -
QBS35_RS05245 1104282..1105088 - 807 WP_043851420.1 tryptophan synthase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1101625..1102605 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49596.72 Da        Isoelectric Point: 6.2243

>T276578 WP_103828447.1 NZ_CP121800:c1099950-1098634 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLLKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVKRRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10570.25 Da        Isoelectric Point: 6.2983

>AT276578 WP_041202615.1 NZ_CP121800:c1100227-1099934 [Aeromonas dhakensis]
MTDTPLPTGTKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVMSSYSQPEVGDDEWF

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References