Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2980603..2982167 Replicon chromosome
Accession NZ_CP121794
Organism Aeromonas caviae strain FIONA 16800

Toxin (Protein)


Gene name hipA Uniprot ID A0A2S4TP05
Locus tag QBS29_RS17130 Protein ID WP_005329232.1
Coordinates 2980603..2981913 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS29_RS17135 Protein ID WP_005329233.1
Coordinates 2981913..2982167 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS29_RS17110 2975944..2976426 - 483 WP_279473735.1 DUF1214 domain-containing protein -
QBS29_RS17115 2976398..2977345 - 948 WP_279473736.1 DUF1254 domain-containing protein -
QBS29_RS17120 2977471..2979645 - 2175 WP_266109744.1 catalase/peroxidase HPI -
QBS29_RS17130 2980603..2981913 - 1311 WP_005329232.1 type II toxin-antitoxin system HipA family toxin Toxin
QBS29_RS17135 2981913..2982167 - 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
QBS29_RS17140 2982669..2982917 + 249 WP_010674978.1 hypothetical protein -
QBS29_RS17145 2983496..2983714 + 219 WP_069785118.1 hypothetical protein -
QBS29_RS17155 2985122..2985793 + 672 WP_069785117.1 site-specific integrase -
QBS29_RS17160 2985749..2986621 - 873 WP_279473737.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49096.31 Da        Isoelectric Point: 7.1717

>T276574 WP_005329232.1 NZ_CP121794:c2981913-2980603 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT276574 WP_005329233.1 NZ_CP121794:c2982167-2981913 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4TP05

Antitoxin

Source ID Structure

References