Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2388611..2390160 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBL01_RS11800 Protein ID WP_160442452.1
Coordinates 2388611..2389927 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag QBL01_RS11805 Protein ID WP_010786623.1
Coordinates 2389921..2390160 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS11780 (QBL01_11780) 2384275..2384901 - 627 WP_261482289.1 DsbA family protein -
QBL01_RS11785 (QBL01_11785) 2384895..2385755 - 861 WP_160448698.1 MBL fold metallo-hydrolase -
QBL01_RS11790 (QBL01_11790) 2385884..2386774 + 891 WP_160448697.1 LysR family transcriptional regulator -
QBL01_RS11795 (QBL01_11795) 2387441..2388607 + 1167 WP_279378719.1 PLP-dependent aminotransferase family protein -
QBL01_RS11800 (QBL01_11800) 2388611..2389927 - 1317 WP_160442452.1 type II toxin-antitoxin system HipA family toxin Toxin
QBL01_RS11805 (QBL01_11805) 2389921..2390160 - 240 WP_010786623.1 XRE family transcriptional regulator Antitoxin
QBL01_RS11810 (QBL01_11810) 2390308..2391135 - 828 WP_005713289.1 alpha/beta hydrolase-fold protein -
QBL01_RS11815 (QBL01_11815) 2391266..2392711 + 1446 WP_035519859.1 metalloprotease TldD -
QBL01_RS11820 (QBL01_11820) 2392965..2393375 + 411 WP_020457617.1 preprotein translocase subunit SecE -
QBL01_RS11825 (QBL01_11825) 2393377..2393955 + 579 WP_020457616.1 transcription termination/antitermination protein NusG -
QBL01_RS11830 (QBL01_11830) 2394067..2394682 + 616 Protein_2292 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 50055.30 Da        Isoelectric Point: 7.6047

>T276572 WP_160442452.1 NZ_CP121769:c2389927-2388611 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLTKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDRVATTLPKQIDENVRDQIFTGVIKQVQKVSMK

Download         Length: 1317 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT276572 WP_010786623.1 NZ_CP121769:c2390160-2389921 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References