Detailed information of TA system TA276571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2228757..2230444
• Replicon: chromosome
• Accession: NZ_CP121769
• Organism: Glaesserella parasuis strain Z44

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U4SB19
• Locus tag: QBL01_RS11055
• Protein ID: WP_021111224.1
• Coordinates: 2229101..2230444 (-)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: QBL01_RS11050
• Protein ID: WP_223300026.1
• Coordinates: 2228757..2229119 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QBL01_RS11025 (QBL01_11025)	2224460..2224828	+	369	WP_160448547.1	hypothetical protein	-
QBL01_RS11030 (QBL01_11030)	2224825..2225775	-	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-
QBL01_RS11035 (QBL01_11035)	2225803..2226648	-	846	WP_021113204.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
QBL01_RS11040 (QBL01_11040)	2226650..2227282	-	633	WP_021110345.1	lipoprotein insertase outer membrane protein LolB	-
QBL01_RS11045 (QBL01_11045)	2227403..2228728	-	1326	WP_021111225.1	ATP-dependent RNA helicase SrmB	-
QBL01_RS11050 (QBL01_11050)	2228757..2229119	-	363	WP_223300026.1	helix-turn-helix transcriptional regulator	Antitoxin
QBL01_RS11055 (QBL01_11055)	2229101..2230444	-	1344	WP_021111224.1	HipA domain-containing protein	Toxin
QBL01_RS11060 (QBL01_11060)	2230558..2230995	-	438	WP_021117780.1	ribosomal protein S18-alanine N-acetyltransferase	-
QBL01_RS11065 (QBL01_11065)	2231170..2231397	+	228	Protein_2150	transposase	-
QBL01_RS11070 (QBL01_11070)	2231477..2233156	-	1680	WP_005713398.1	DNA repair protein RecN	-
QBL01_RS11075 (QBL01_11075)	2233399..2233635	-	237	WP_234799277.1	hypothetical protein	-
QBL01_RS11080 (QBL01_11080)	2233801..2234664	+	864	WP_075604875.1	tetratricopeptide repeat protein	-
QBL01_RS11085 (QBL01_11085)	2234666..2235205	+	540	WP_075604874.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2231146..2231397	251

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (161-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-98)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 51106.20 Da
• Isoelectric Point: 5.4867

>T276571 WP_021111224.1 NZ_CP121769:c2230444-2229101 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Nucleotide

• Length: 1344 bp

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13880.42 Da
• Isoelectric Point: 10.2782

>AT276571 WP_223300026.1 NZ_CP121769:c2229119-2228757 [Glaesserella parasuis]
MAIIIIMEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLEN
DKGNYSIDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Nucleotide

• Length: 363 bp

Structures

Toxin

• AlphaFold DB: U4SB19