Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1993252..1993832 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name mazF Uniprot ID A0A143CFE3
Locus tag QBL01_RS09905 Protein ID WP_005710599.1
Coordinates 1993488..1993832 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag QBL01_RS09900 Protein ID WP_005710601.1
Coordinates 1993252..1993491 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS09875 (QBL01_09875) 1988956..1989648 - 693 WP_021118715.1 tellurite resistance TerB family protein -
QBL01_RS09880 (QBL01_09880) 1989710..1990558 - 849 WP_279378418.1 ABC transporter permease subunit -
QBL01_RS09885 (QBL01_09885) 1990555..1991340 - 786 WP_279378419.1 ABC transporter permease subunit -
QBL01_RS09890 (QBL01_09890) 1991330..1992079 - 750 WP_279378420.1 phosphonate ABC transporter ATP-binding protein -
QBL01_RS09895 (QBL01_09895) 1992191..1993066 - 876 WP_279378421.1 putative selenate ABC transporter substrate-binding protein -
QBL01_RS09900 (QBL01_09900) 1993252..1993491 + 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QBL01_RS09905 (QBL01_09905) 1993488..1993832 + 345 WP_005710599.1 endoribonuclease MazF Toxin
QBL01_RS09910 (QBL01_09910) 1993838..1994506 + 669 WP_021118711.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QBL01_RS09915 (QBL01_09915) 1994519..1995910 + 1392 WP_279378422.1 MATE family efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12830.81 Da        Isoelectric Point: 7.9277

>T276570 WP_005710599.1 NZ_CP121769:1993488-1993832 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPTIYNRQTGLLICCPLTTKVKGYPFEVNIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT276570 WP_005710601.1 NZ_CP121769:1993252-1993491 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CFE3

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References