Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1915224..1915759 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag QBL01_RS09510 Protein ID WP_010785923.1
Coordinates 1915224..1915508 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag QBL01_RS09515 Protein ID WP_021118772.1
Coordinates 1915505..1915759 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS09485 (QBL01_09485) 1910370..1910861 + 492 WP_005712683.1 acetolactate synthase small subunit -
QBL01_RS09490 (QBL01_09490) 1910968..1911789 - 822 WP_042906514.1 PHP domain-containing protein -
QBL01_RS09495 (QBL01_09495) 1911790..1912386 - 597 WP_020996918.1 uracil DNA glycosylase superfamily protein -
QBL01_RS09500 (QBL01_09500) 1912421..1913380 - 960 WP_021117960.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
QBL01_RS09505 (QBL01_09505) 1913463..1915013 - 1551 WP_021112100.1 exodeoxyribonuclease I -
QBL01_RS09510 (QBL01_09510) 1915224..1915508 - 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBL01_RS09515 (QBL01_09515) 1915505..1915759 - 255 WP_021118772.1 hypothetical protein Antitoxin
QBL01_RS09520 (QBL01_09520) 1915876..1916631 - 756 WP_160444822.1 ABC transporter permease -
QBL01_RS09525 (QBL01_09525) 1916653..1917549 - 897 WP_005712691.1 ABC transporter ATP-binding protein -
QBL01_RS09530 (QBL01_09530) 1917697..1917864 - 168 Protein_1860 ATP-binding cassette domain-containing protein -
QBL01_RS09535 (QBL01_09535) 1917870..1919882 - 2013 WP_160444821.1 DNA polymerase III subunit gamma/tau -
QBL01_RS09540 (QBL01_09540) 1919969..1920511 - 543 WP_021112096.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T276569 WP_010785923.1 NZ_CP121769:c1915508-1915224 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT276569 WP_021118772.1 NZ_CP121769:c1915759-1915505 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References