Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1122958..1123735 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A836YXW5
Locus tag QBL01_RS05590 Protein ID WP_016527794.1
Coordinates 1122958..1123458 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag QBL01_RS05595 Protein ID WP_005710653.1
Coordinates 1123448..1123735 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS05555 (QBL01_05555) 1118084..1118239 - 156 WP_021111605.1 YoaH family protein -
QBL01_RS05560 (QBL01_05560) 1118257..1118985 - 729 WP_279378683.1 tRNA pseudouridine(65) synthase TruC -
QBL01_RS05565 (QBL01_05565) 1118982..1119296 - 315 WP_005710664.1 YqcC family protein -
QBL01_RS05570 (QBL01_05570) 1119338..1120252 - 915 WP_279378684.1 N-acetylmuramic acid 6-phosphate etherase -
QBL01_RS05575 (QBL01_05575) 1120264..1121379 - 1116 WP_016527792.1 anhydro-N-acetylmuramic acid kinase -
QBL01_RS05580 (QBL01_05580) 1121533..1121868 - 336 WP_016527793.1 outer membrane protein assembly factor BamE -
QBL01_RS05585 (QBL01_05585) 1121929..1122930 - 1002 WP_010786647.1 nucleoid-associated protein YejK -
QBL01_RS05590 (QBL01_05590) 1122958..1123458 - 501 WP_016527794.1 GNAT family N-acetyltransferase Toxin
QBL01_RS05595 (QBL01_05595) 1123448..1123735 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
QBL01_RS05600 (QBL01_05600) 1123881..1124270 + 390 WP_021116694.1 RidA family protein -
QBL01_RS05605 (QBL01_05605) 1124274..1125011 + 738 WP_021109669.1 peptidoglycan editing factor PgeF -
QBL01_RS05610 (QBL01_05610) 1125186..1126763 + 1578 WP_021116696.1 FAD-binding protein -
QBL01_RS05615 (QBL01_05615) 1126867..1127367 + 501 WP_021115009.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19081.26 Da        Isoelectric Point: 9.2835

>T276565 WP_016527794.1 NZ_CP121769:c1123458-1122958 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT276565 WP_005710653.1 NZ_CP121769:c1123735-1123448 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YXW5

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References