Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2058017..2059572 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBK97_RS10160 Protein ID WP_160413780.1
Coordinates 2058017..2059339 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag QBK97_RS10165 Protein ID WP_010786623.1
Coordinates 2059333..2059572 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS10140 (QBK97_10140) 2054973..2055845 + 873 WP_075630953.1 LysR family transcriptional regulator -
QBK97_RS10145 (QBK97_10145) 2055906..2056526 - 621 WP_075630952.1 DsbA family protein -
QBK97_RS10150 (QBK97_10150) 2056750..2057364 + 615 WP_279368243.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
QBK97_RS10155 (QBK97_10155) 2057348..2058013 + 666 WP_279368244.1 PLP-dependent aminotransferase family protein -
QBK97_RS10160 (QBK97_10160) 2058017..2059339 - 1323 WP_160413780.1 HipA domain-containing protein Toxin
QBK97_RS10165 (QBK97_10165) 2059333..2059572 - 240 WP_010786623.1 XRE family transcriptional regulator Antitoxin
QBK97_RS10170 (QBK97_10170) 2059720..2060547 - 828 WP_279368245.1 alpha/beta hydrolase-fold protein -
QBK97_RS10175 (QBK97_10175) 2060678..2062123 + 1446 WP_021116416.1 metalloprotease TldD -
QBK97_RS10180 (QBK97_10180) 2062377..2062787 + 411 WP_020457617.1 preprotein translocase subunit SecE -
QBK97_RS10185 (QBK97_10185) 2062789..2063367 + 579 WP_020457616.1 transcription termination/antitermination protein NusG -
QBK97_RS10190 (QBK97_10190) 2063477..2064023 + 547 Protein_1966 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2063477..2063947 470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50185.46 Da        Isoelectric Point: 7.3465

>T276564 WP_160413780.1 NZ_CP121768:c2059339-2058017 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSL
AIEKQGRYHLSPVYDVISAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQIC
DTVQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1323 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT276564 WP_010786623.1 NZ_CP121768:c2059572-2059333 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References