Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 678550..679085 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag QBK97_RS03455 Protein ID WP_010785923.1
Coordinates 678801..679085 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag QBK97_RS03450 Protein ID WP_021118772.1
Coordinates 678550..678804 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS03430 (QBK97_03430) 674105..674647 + 543 WP_010785927.1 adenine phosphoribosyltransferase -
QBK97_RS03435 (QBK97_03435) 674736..676754 + 2019 WP_160429885.1 DNA polymerase III subunit gamma/tau -
QBK97_RS03440 (QBK97_03440) 676760..677656 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
QBK97_RS03445 (QBK97_03445) 677678..678433 + 756 WP_021112098.1 ABC transporter permease -
QBK97_RS03450 (QBK97_03450) 678550..678804 + 255 WP_021118772.1 hypothetical protein Antitoxin
QBK97_RS03455 (QBK97_03455) 678801..679085 + 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBK97_RS03460 (QBK97_03460) 679295..680845 + 1551 WP_010785922.1 exodeoxyribonuclease I -
QBK97_RS03465 (QBK97_03465) 680928..681887 + 960 WP_005712686.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
QBK97_RS03470 (QBK97_03470) 681922..682518 + 597 WP_020996918.1 uracil DNA glycosylase superfamily protein -
QBK97_RS03475 (QBK97_03475) 682519..683340 + 822 WP_021116604.1 PHP domain-containing protein -
QBK97_RS03480 (QBK97_03480) 683447..683938 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T276559 WP_010785923.1 NZ_CP121768:678801-679085 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT276559 WP_021118772.1 NZ_CP121768:678550-678804 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References