Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 594249..594829 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name mazF Uniprot ID U4SBB4
Locus tag QBK97_RS03060 Protein ID WP_021113409.1
Coordinates 594249..594593 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag QBK97_RS03065 Protein ID WP_005710601.1
Coordinates 594590..594829 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS03050 (QBK97_03050) 592171..593562 - 1392 WP_021116571.1 MATE family efflux transporter -
QBK97_RS03055 (QBK97_03055) 593575..594243 - 669 WP_010785979.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QBK97_RS03060 (QBK97_03060) 594249..594593 - 345 WP_021113409.1 endoribonuclease MazF Toxin
QBK97_RS03065 (QBK97_03065) 594590..594829 - 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QBK97_RS03070 (QBK97_03070) 595015..595890 + 876 WP_021113313.1 putative selenate ABC transporter substrate-binding protein -
QBK97_RS03075 (QBK97_03075) 596002..596751 + 750 WP_005710605.1 phosphonate ABC transporter ATP-binding protein -
QBK97_RS03080 (QBK97_03080) 596741..597526 + 786 WP_160427666.1 ABC transporter permease subunit -
QBK97_RS03085 (QBK97_03085) 597523..598371 + 849 WP_042905731.1 ABC transporter permease subunit -
QBK97_RS03090 (QBK97_03090) 598433..599125 + 693 WP_021118715.1 tellurite resistance TerB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12800.79 Da        Isoelectric Point: 7.9277

>T276558 WP_021113409.1 NZ_CP121768:c594593-594249 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVNIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT276558 WP_005710601.1 NZ_CP121768:c594829-594590 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SBB4

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References