Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 380352..380991 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name relE Uniprot ID A0A6I4QYS7
Locus tag QBK97_RS01990 Protein ID WP_021114433.1
Coordinates 380656..380991 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QBK97_RS01985 Protein ID WP_164681833.1
Coordinates 380352..380648 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS01960 (QBK97_01960) 375406..376593 + 1188 WP_016527483.1 elongation factor Tu -
QBK97_RS01965 (QBK97_01965) 376956..377525 - 570 WP_231401385.1 hypothetical protein -
QBK97_RS01970 (QBK97_01970) 377706..378035 + 330 Protein_371 transposase -
QBK97_RS01975 (QBK97_01975) 378063..379189 - 1127 Protein_372 IS3 family transposase -
QBK97_RS01980 (QBK97_01980) 379290..380279 - 990 WP_021116485.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
QBK97_RS01985 (QBK97_01985) 380352..380648 - 297 WP_164681833.1 putative addiction module antidote protein Antitoxin
QBK97_RS01990 (QBK97_01990) 380656..380991 - 336 WP_021114433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBK97_RS01995 (QBK97_01995) 381150..381554 + 405 WP_021110905.1 DNA polymerase III subunit psi -
QBK97_RS02000 (QBK97_02000) 381669..381980 + 312 WP_042906459.1 hypothetical protein -
QBK97_RS02005 (QBK97_02005) 382074..383012 + 939 WP_160427824.1 oligoendopeptidase F family protein -
QBK97_RS02010 (QBK97_02010) 383104..383847 + 744 Protein_379 IS481 family transposase -
QBK97_RS02015 (QBK97_02015) 384036..384221 - 186 WP_005713975.1 zf-HC2 domain-containing protein -
QBK97_RS02020 (QBK97_02020) 384218..384790 - 573 WP_035522608.1 sigma-70 family RNA polymerase sigma factor -
QBK97_RS02025 (QBK97_02025) 384932..385261 + 330 WP_021113605.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 377706..389384 11678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12079.77 Da        Isoelectric Point: 9.8168

>T276556 WP_021114433.1 NZ_CP121768:c380991-380656 [Glaesserella parasuis]
MSGIINQIVITDNFSKWLDGLKNPIAKATVARRIKNAVKGNFGDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTQQADIEKAKALWAELKQTGGSNEY

Download         Length: 336 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10948.49 Da        Isoelectric Point: 4.8951

>AT276556 WP_164681833.1 NZ_CP121768:c380648-380352 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I4QYS7

Antitoxin

Source ID Structure

References