Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 287939..289626 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name hipA Uniprot ID U4SB19
Locus tag QBK97_RS01500 Protein ID WP_021111224.1
Coordinates 287939..289282 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBK97_RS01505 Protein ID WP_015940035.1
Coordinates 289282..289626 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS01475 (QBK97_01475) 283911..284753 - 843 WP_051621427.1 TonB-dependent receptor -
QBK97_RS01480 (QBK97_01480) 284787..285014 + 228 WP_062924031.1 hypothetical protein -
QBK97_RS01485 (QBK97_01485) 285228..286907 + 1680 WP_075630648.1 DNA repair protein RecN -
QBK97_RS01490 (QBK97_01490) 286987..287214 - 228 Protein_282 transposase -
QBK97_RS01495 (QBK97_01495) 287388..287825 + 438 WP_075630649.1 ribosomal protein S18-alanine N-acetyltransferase -
QBK97_RS01500 (QBK97_01500) 287939..289282 + 1344 WP_021111224.1 HipA domain-containing protein Toxin
QBK97_RS01505 (QBK97_01505) 289282..289626 + 345 WP_015940035.1 helix-turn-helix transcriptional regulator Antitoxin
QBK97_RS01510 (QBK97_01510) 289655..290980 + 1326 WP_021117781.1 ATP-dependent RNA helicase SrmB -
QBK97_RS01515 (QBK97_01515) 291101..291733 + 633 WP_021110345.1 lipoprotein insertase outer membrane protein LolB -
QBK97_RS01520 (QBK97_01520) 291735..292580 + 846 WP_021113204.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QBK97_RS01525 (QBK97_01525) 292608..293558 + 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 286987..287238 251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51106.20 Da        Isoelectric Point: 5.4867

>T276555 WP_021111224.1 NZ_CP121768:287939-289282 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13225.52 Da        Isoelectric Point: 10.2782

>AT276555 WP_015940035.1 NZ_CP121768:289282-289626 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SB19

Antitoxin

Source ID Structure

References