276551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4226646..4227232 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag QAY87_RS20020 Protein ID WP_003120987.1
Coordinates 4226933..4227232 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag QAY87_RS20015 Protein ID WP_003448662.1
Coordinates 4226646..4226936 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS19995 (QAY87_19990) 4222222..4224117 + 1896 WP_023435882.1 hypothetical protein -
QAY87_RS20000 (QAY87_19995) 4224114..4226090 + 1977 WP_031285653.1 DEAD/DEAH box helicase -
QAY87_RS20005 (QAY87_20000) 4226100..4226234 + 135 WP_033179080.1 hypothetical protein -
QAY87_RS20010 (QAY87_20005) 4226231..4226575 + 345 WP_003448665.1 hypothetical protein -
QAY87_RS20015 (QAY87_20010) 4226646..4226936 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
QAY87_RS20020 (QAY87_20015) 4226933..4227232 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QAY87_RS20025 (QAY87_20020) 4227433..4228557 + 1125 WP_023435880.1 TcpQ domain-containing protein -
QAY87_RS20030 (QAY87_20025) 4228557..4230266 + 1710 WP_023435879.1 PilN family type IVB pilus formation outer membrane protein -
QAY87_RS20035 (QAY87_20030) 4230270..4231595 + 1326 WP_023435878.1 type 4b pilus protein PilO2 -
QAY87_RS20040 (QAY87_20035) 4231585..4232118 + 534 WP_023435877.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4201361..4317886 116525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T276551 WP_003120987.1 NZ_CP121766:c4227232-4226933 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT276551 WP_003448662.1 NZ_CP121766:c4226936-4226646 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References