276550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4142547..4143805 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QAY87_RS19550 Protein ID WP_003086331.1
Coordinates 4142547..4143302 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QAY87_RS19555 Protein ID WP_003086329.1
Coordinates 4143437..4143805 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS19540 (QAY87_19535) 4137718..4140261 + 2544 WP_034024564.1 acyl-homoserine-lactone acylase QuiP -
QAY87_RS19545 (QAY87_19540) 4140416..4141777 - 1362 WP_003134034.1 DNA recombination protein RmuC -
QAY87_RS19550 (QAY87_19545) 4142547..4143302 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QAY87_RS19555 (QAY87_19550) 4143437..4143805 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QAY87_RS19560 (QAY87_19555) 4143878..4145164 - 1287 WP_023435242.1 FAD-binding oxidoreductase -
QAY87_RS19565 (QAY87_19560) 4145220..4146711 - 1492 Protein_3874 aldehyde dehydrogenase family protein -
QAY87_RS19570 (QAY87_19565) 4146885..4147361 + 477 WP_009877993.1 elongation factor GreAB -
QAY87_RS19575 (QAY87_19570) 4147364..4147519 - 156 WP_015503364.1 zinc ribbon domain-containing protein -
QAY87_RS19580 (QAY87_19575) 4147544..4147678 + 135 WP_023435240.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T276550 WP_003086331.1 NZ_CP121766:c4143302-4142547 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT276550 WP_003086329.1 NZ_CP121766:c4143805-4143437 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References