276549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3159925..3161146 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag QAY87_RS14905 Protein ID WP_003102740.1
Coordinates 3160568..3161146 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QAY87_RS14900 Protein ID WP_023436381.1
Coordinates 3159925..3160479 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS14875 (QAY87_14875) 3155493..3156044 + 552 WP_023436384.1 XRE family transcriptional regulator -
QAY87_RS14880 (QAY87_14880) 3156041..3156439 - 399 WP_023436383.1 NADH-quinone oxidoreductase subunit A -
QAY87_RS14885 (QAY87_14885) 3156452..3156775 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QAY87_RS14890 (QAY87_14890) 3157106..3157567 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QAY87_RS14895 (QAY87_14895) 3157572..3159767 + 2196 WP_023436382.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QAY87_RS14900 (QAY87_14900) 3159925..3160479 + 555 WP_023436381.1 helix-turn-helix transcriptional regulator Antitoxin
QAY87_RS14905 (QAY87_14905) 3160568..3161146 + 579 WP_003102740.1 HD domain-containing protein Toxin
QAY87_RS14910 (QAY87_14910) 3161255..3162442 - 1188 WP_023106616.1 HlyD family efflux transporter periplasmic adaptor subunit -
QAY87_RS14915 (QAY87_14915) 3162432..3164603 - 2172 WP_023436380.1 type I secretion system permease/ATPase -
QAY87_RS14920 (QAY87_14920) 3164593..3165869 - 1277 Protein_2951 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T276549 WP_003102740.1 NZ_CP121766:3160568-3161146 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20469.69 Da        Isoelectric Point: 8.9481

>AT276549 WP_023436381.1 NZ_CP121766:3159925-3160479 [Pseudomonas aeruginosa]
MTKPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References