Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1195201..1196709 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QAY87_RS05685 Protein ID WP_023434930.1
Coordinates 1195201..1195788 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag QAY87_RS05690 Protein ID WP_003091607.1
Coordinates 1195855..1196709 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS05680 (QAY87_05680) 1191457..1194936 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QAY87_RS05685 (QAY87_05685) 1195201..1195788 + 588 WP_023434930.1 GNAT family protein Toxin
QAY87_RS05690 (QAY87_05690) 1195855..1196709 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
QAY87_RS05695 (QAY87_05695) 1196806..1198971 + 2166 WP_023434929.1 TonB-dependent receptor family protein -
QAY87_RS05700 (QAY87_05700) 1199146..1201020 + 1875 WP_003091605.1 MFS transporter -
QAY87_RS05705 (QAY87_05705) 1201081..1201290 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21917.23 Da        Isoelectric Point: 9.8676

>T276548 WP_023434930.1 NZ_CP121766:1195201-1195788 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRSQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT276548 WP_003091607.1 NZ_CP121766:1195855-1196709 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References