276547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 886914..888609 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name doc Uniprot ID A0A7M3AXJ1
Locus tag QAY87_RS04095 Protein ID WP_058201625.1
Coordinates 886914..887783 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7M3AXM3
Locus tag QAY87_RS04100 Protein ID WP_023108658.1
Coordinates 887776..888609 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS04070 (QAY87_04070) 882923..883774 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QAY87_RS04075 (QAY87_04075) 883814..884821 + 1008 WP_023108660.1 ABC transporter substrate-binding protein -
QAY87_RS04080 (QAY87_04080) 884818..885594 + 777 WP_003112898.1 ABC transporter permease -
QAY87_RS04085 (QAY87_04085) 885600..886361 + 762 WP_003112899.1 SDR family oxidoreductase -
QAY87_RS04090 (QAY87_04090) 886375..886905 + 531 WP_003112900.1 cupin domain-containing protein -
QAY87_RS04095 (QAY87_04095) 886914..887783 + 870 WP_058201625.1 alpha/beta hydrolase Toxin
QAY87_RS04100 (QAY87_04100) 887776..888609 + 834 WP_023108658.1 IclR family transcriptional regulator Antitoxin
QAY87_RS04105 (QAY87_04105) 888596..889393 + 798 WP_003112903.1 SDR family oxidoreductase -
QAY87_RS04110 (QAY87_04110) 889386..891068 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
QAY87_RS04115 (QAY87_04115) 891079..891882 + 804 WP_003112905.1 aspartate dehydrogenase -
QAY87_RS04120 (QAY87_04120) 891894..893378 + 1485 WP_058201624.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30374.68 Da        Isoelectric Point: 6.8139

>T276547 WP_058201625.1 NZ_CP121766:886914-887783 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRLRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30819.22 Da        Isoelectric Point: 6.1414

>AT276547 WP_023108658.1 NZ_CP121766:887776-888609 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPARIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M3AXJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A7M3AXM3

References