Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 5450408..5450985 Replicon chromosome
Accession NZ_CP121700
Organism Methylobacterium indicum strain JDJ13

Toxin (Protein)


Gene name PumA Uniprot ID A0A0J6RSB8
Locus tag QBE04_RS25295 Protein ID WP_048425788.1
Coordinates 5450692..5450985 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0J6RRU8
Locus tag QBE04_RS25290 Protein ID WP_048425789.1
Coordinates 5450408..5450689 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBE04_RS25265 5446375..5446689 - 315 WP_058617343.1 hypothetical protein -
QBE04_RS25270 5446740..5447795 - 1056 WP_279357215.1 GTP-binding protein -
QBE04_RS25275 5447792..5448085 - 294 WP_279357216.1 hypothetical protein -
QBE04_RS25280 5448090..5448989 - 900 WP_279357217.1 polysaccharide deacetylase -
QBE04_RS25290 5450408..5450689 - 282 WP_048425789.1 hypothetical protein Antitoxin
QBE04_RS25295 5450692..5450985 - 294 WP_048425788.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBE04_RS25300 5451083..5453512 - 2430 WP_279357218.1 penicillin-binding protein 1A -
QBE04_RS25305 5453717..5455081 - 1365 WP_279357219.1 N-acetylmuramoyl-L-alanine amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(43-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11006.62 Da        Isoelectric Point: 10.4157

>T276544 WP_048425788.1 NZ_CP121700:c5450985-5450692 [Methylobacterium indicum]
MIRIRQTATFRRWEQQLKDQRARTVIAARLLRLANGLVGDAAPVGRGVSELRIHYGPGYRIYFQRRGDDIVILLCGGDKA
SQDRDIQKALQLAEEEG

Download         Length: 294 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9786.05 Da        Isoelectric Point: 3.9820

>AT276544 WP_048425789.1 NZ_CP121700:c5450689-5450408 [Methylobacterium indicum]
MAEEITDFDFAASLQSDEAIAIFLSDAFETGDANHIAAALEIAIRAKGEARIASRAEIPENGYDLDNPTLATMLAVMKAL
GVGFSPMPVRAAS

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6RSB8

Antitoxin

Source ID Structure
AlphaFold DB A0A0J6RRU8

References