Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3865255..3865913 Replicon chromosome
Accession NZ_CP121700
Organism Methylobacterium indicum strain JDJ13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QBE04_RS17810 Protein ID WP_279356347.1
Coordinates 3865509..3865913 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QBE04_RS17805 Protein ID WP_058618043.1
Coordinates 3865255..3865512 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBE04_RS17780 3860805..3861464 + 660 WP_048428139.1 GTP cyclohydrolase I FolE -
QBE04_RS17785 3861467..3861883 + 417 WP_089504160.1 phosphoribosyl-AMP cyclohydrolase -
QBE04_RS17790 3861933..3862349 - 417 WP_048428162.1 gamma-glutamylcyclotransferase family protein -
QBE04_RS17795 3862360..3864363 - 2004 WP_058618044.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
QBE04_RS17800 3864549..3864995 - 447 WP_279356346.1 hypothetical protein -
QBE04_RS17805 3865255..3865512 + 258 WP_058618043.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QBE04_RS17810 3865509..3865913 + 405 WP_279356347.1 type II toxin-antitoxin system VapC family toxin Toxin
QBE04_RS17815 3865991..3866440 - 450 WP_279356348.1 hypothetical protein -
QBE04_RS17820 3866689..3867288 - 600 WP_279356349.1 L,D-transpeptidase -
QBE04_RS17825 3867485..3868414 + 930 WP_048428147.1 histone deacetylase family protein -
QBE04_RS17830 3868607..3869176 - 570 WP_279356350.1 hypothetical protein -
QBE04_RS17835 3869228..3870427 - 1200 WP_279356351.1 succinyl-diaminopimelate desuccinylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-127)

Antitoxin

SpoVT-AbrB domain

(16-58)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14304.54 Da        Isoelectric Point: 6.3492

>T276541 WP_279356347.1 NZ_CP121700:3865509-3865913 [Methylobacterium indicum]
MSGPRFLLDTNILSDLIRNPSGAVARQIARVGSKGIATSIVSVAELRYGCAKRGSARLLRQVEAVLEAIDVVPFETPADV
IYGRIRADLEAAGRPIGPNDLLIAAQALALEVPLVTANEAEFRRVGGLTVENWL

Download         Length: 405 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9660.03 Da        Isoelectric Point: 4.3115

>AT276541 WP_058618043.1 NZ_CP121700:3865255-3865512 [Methylobacterium indicum]
MARPTPIPQAREVKLFRNNRSQAVRIPAEFALPGDRVRISRDGDRLILEPIGKKDLLEVLATLEPIEEDFPDFDETLPPL
DDDPL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References