Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 300995..301645 Replicon chromosome
Accession NZ_CP121700
Organism Methylobacterium indicum strain JDJ13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QBE04_RS01405 Protein ID WP_279357980.1
Coordinates 300995..301204 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QBE04_RS01410 Protein ID WP_279357981.1
Coordinates 301241..301645 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBE04_RS01385 296310..296963 + 654 WP_048429360.1 amino acid ABC transporter permease -
QBE04_RS01390 296960..297760 + 801 WP_279357977.1 amino acid ABC transporter ATP-binding protein -
QBE04_RS01395 297944..298891 + 948 WP_279357978.1 agmatinase -
QBE04_RS01400 299161..300771 + 1611 WP_279357979.1 galactarate dehydratase -
QBE04_RS01405 300995..301204 + 210 WP_279357980.1 type II toxin-antitoxin system HicA family toxin Toxin
QBE04_RS01410 301241..301645 + 405 WP_279357981.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QBE04_RS01415 301679..302572 - 894 WP_279357982.1 hydroxymethylglutaryl-CoA lyase -
QBE04_RS01420 302569..303789 - 1221 WP_279357983.1 ABC transporter substrate-binding protein -
QBE04_RS01425 304052..305335 - 1284 WP_279357984.1 hydroxymethylglutaryl-CoA reductase, degradative -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-67)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-126)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7786.92 Da        Isoelectric Point: 10.7459

>T276539 WP_279357980.1 NZ_CP121700:300995-301204 [Methylobacterium indicum]
MAPKQRSRKTRDVLAMLVKDGWFVARKGPGDHVQYKHPTKPGKVTVDSGASEIPTGTLHNIYRQAGWEW

Download         Length: 210 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14283.17 Da        Isoelectric Point: 4.4323

>AT276539 WP_279357981.1 NZ_CP121700:301241-301645 [Methylobacterium indicum]
MVRIVMLVHEEEGVFGASFPDFPGATTVADDLDTLYRKAAEMLAFHVNGMAEDGDAIPALRTLSELQQDPVFRDDSEGAM
IGLVDVDLPGKAVRVNVSIEEGLLKRIDHAAAAAGESRSSFLARAARARLSTAA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References