Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5278554..5279118 Replicon chromosome
Accession NZ_CP121682
Organism Streptomyces sp. HUAS 5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PYS65_RS24070 Protein ID WP_279336020.1
Coordinates 5278792..5279118 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PYS65_RS24065 Protein ID WP_279336019.1
Coordinates 5278554..5278784 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYS65_RS24045 (PYS65_24045) 5274204..5274491 + 288 WP_279336015.1 hypothetical protein -
PYS65_RS24050 (PYS65_24050) 5274716..5274940 + 225 WP_279336016.1 hypothetical protein -
PYS65_RS24055 (PYS65_24055) 5275229..5277823 - 2595 WP_279336017.1 aminopeptidase N -
PYS65_RS24060 (PYS65_24060) 5277936..5278430 + 495 WP_279336018.1 DUF1203 domain-containing protein -
PYS65_RS24065 (PYS65_24065) 5278554..5278784 + 231 WP_279336019.1 ribbon-helix-helix domain-containing protein Antitoxin
PYS65_RS24070 (PYS65_24070) 5278792..5279118 + 327 WP_279336020.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYS65_RS24075 (PYS65_24075) 5279180..5280196 - 1017 WP_279336021.1 aspartate-semialdehyde dehydrogenase -
PYS65_RS24080 (PYS65_24080) 5280527..5281066 + 540 WP_279336022.1 sigma-70 family RNA polymerase sigma factor -
PYS65_RS24085 (PYS65_24085) 5281068..5281886 + 819 WP_279336023.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11861.63 Da        Isoelectric Point: 10.7240

>T276534 WP_279336020.1 NZ_CP121682:5278792-5279118 [Streptomyces sp. HUAS 5]
MVDLEPARGSEANKVRPAVIVSNNAANESVVQHNRGVVTVVPLTSNTSRVLTFQVFLSSDESRLPKDSKVQCEQVRAVAP
DRLLHKVGAVPRQRMAEIDVALRRHLAL

Download         Length: 327 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8410.15 Da        Isoelectric Point: 3.7947

>AT276534 WP_279336019.1 NZ_CP121682:5278554-5278784 [Streptomyces sp. HUAS 5]
MKISVSLPKEDLAFVDEYAARTEAESRSAVIQAAIELLRQAQLEQEYTEAFAEWDGSGDAGLWDRTSGDGITDEAW

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References