Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4876976..4877541 Replicon chromosome
Accession NZ_CP121682
Organism Streptomyces sp. HUAS 5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PYS65_RS22315 Protein ID WP_279335708.1
Coordinates 4877173..4877541 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A101UWX4
Locus tag PYS65_RS22310 Protein ID WP_060892904.1
Coordinates 4876976..4877173 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYS65_RS22275 (PYS65_22275) 4873030..4873386 - 357 WP_279335702.1 MerR family transcriptional regulator -
PYS65_RS22280 (PYS65_22280) 4873476..4873937 + 462 WP_279335703.1 hypothetical protein -
PYS65_RS22285 (PYS65_22285) 4874001..4874330 - 330 WP_279335704.1 hypothetical protein -
PYS65_RS22290 (PYS65_22290) 4874327..4874635 - 309 WP_279335705.1 hypothetical protein -
PYS65_RS22295 (PYS65_22295) 4874782..4875012 + 231 WP_279335706.1 GntR family transcriptional regulator -
PYS65_RS22305 (PYS65_22305) 4875465..4876943 + 1479 WP_279335707.1 MFS transporter -
PYS65_RS22310 (PYS65_22310) 4876976..4877173 + 198 WP_060892904.1 hypothetical protein Antitoxin
PYS65_RS22315 (PYS65_22315) 4877173..4877541 + 369 WP_279335708.1 Fic family protein Toxin
PYS65_RS22320 (PYS65_22320) 4877675..4879465 + 1791 WP_279335709.1 DEAD/DEAH box helicase -
PYS65_RS22325 (PYS65_22325) 4879760..4880401 + 642 WP_279335710.1 helix-turn-helix domain-containing protein -
PYS65_RS22330 (PYS65_22330) 4880536..4881327 + 792 WP_279335711.1 S16 family serine protease -
PYS65_RS22335 (PYS65_22335) 4881341..4882309 - 969 WP_279335712.1 glycine betaine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13709.60 Da        Isoelectric Point: 5.1138

>T276533 WP_279335708.1 NZ_CP121682:4877173-4877541 [Streptomyces sp. HUAS 5]
MHYLTLPELLNLAKRLGEDAVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLAWYATWVFL
HMNGHALDPDFDVDEAERFVLDVCQGALDVPKIASQLPRFAR

Download         Length: 369 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7176.03 Da        Isoelectric Point: 5.5760

>AT276533 WP_060892904.1 NZ_CP121682:4876976-4877173 [Streptomyces sp. HUAS 5]
MAGLNLRFTDEELDALRERAAAEGRSMQAFAHDAVVAAINEHSRLFNEAAEHVLKASAELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A101UWX4

References