Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-higA/VapC-couple_hipB
Location 4669212..4669888 Replicon chromosome
Accession NZ_CP121682
Organism Streptomyces sp. HUAS 5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYS65_RS21450 Protein ID WP_279335548.1
Coordinates 4669466..4669888 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYS65_RS21445 Protein ID WP_279335547.1
Coordinates 4669212..4669445 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYS65_RS21425 (PYS65_21425) 4665580..4665765 - 186 WP_279335545.1 antitoxin -
PYS65_RS21430 (PYS65_21430) 4666065..4666775 + 711 WP_279338026.1 HNH endonuclease family protein -
PYS65_RS21435 (PYS65_21435) 4666938..4667624 + 687 WP_279335546.1 hypothetical protein -
PYS65_RS21440 (PYS65_21440) 4667663..4669159 + 1497 WP_279338027.1 protein kinase -
PYS65_RS21445 (PYS65_21445) 4669212..4669445 - 234 WP_279335547.1 helix-turn-helix transcriptional regulator Antitoxin
PYS65_RS21450 (PYS65_21450) 4669466..4669888 - 423 WP_279335548.1 PIN domain nuclease Toxin
PYS65_RS21455 (PYS65_21455) 4669885..4670085 - 201 WP_279335549.1 hypothetical protein -
PYS65_RS21460 (PYS65_21460) 4670490..4671134 + 645 WP_279335550.1 SurA N-terminal domain-containing protein -
PYS65_RS21465 (PYS65_21465) 4671219..4672235 + 1017 WP_279335551.1 nucleoside triphosphate pyrophosphohydrolase -
PYS65_RS21470 (PYS65_21470) 4672298..4673584 + 1287 WP_279335552.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-70)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15353.46 Da        Isoelectric Point: 5.9868

>T276532 WP_279335548.1 NZ_CP121682:c4669888-4669466 [Streptomyces sp. HUAS 5]
VSKAFLIDTSACNRLFRLPGVEREWAQVLDAGRVSVCEVTELELVRAAGGREERALLDRYLHDAFGWTPAPERTLLRARQ
VQELLVTSGQHHGPGAVDLMVAATAELSGLVLLHYDADFEAIAKATGQPHRWIAPRGSVD

Download         Length: 423 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8312.38 Da        Isoelectric Point: 10.3891

>AT276532 WP_279335547.1 NZ_CP121682:c4669445-4669212 [Streptomyces sp. HUAS 5]
MHTKTQLRTGPEDVARFLRQLREAHGLSQRALATRLGVSQARVARLESGANNPQLDTLAAYVAALGGTLSLHADFDT

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References