Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3965689..3966362 Replicon chromosome
Accession NZ_CP121679
Organism Ancylobacter sp. WKF20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AncyloWKF20_RS18395 Protein ID WP_279315402.1
Coordinates 3965689..3966111 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AncyloWKF20_RS18400 Protein ID WP_279315403.1
Coordinates 3966108..3966362 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AncyloWKF20_RS18350 (AncyloWKF20_18350) 3960770..3961657 - 888 WP_279315394.1 replication initiator protein A -
AncyloWKF20_RS18355 (AncyloWKF20_18355) 3961664..3961945 - 282 WP_279315395.1 helix-turn-helix domain-containing protein -
AncyloWKF20_RS18360 (AncyloWKF20_18360) 3962068..3962478 - 411 WP_279315396.1 DUF2285 domain-containing protein -
AncyloWKF20_RS18365 (AncyloWKF20_18365) 3962459..3962800 - 342 WP_279315397.1 DUF6499 domain-containing protein -
AncyloWKF20_RS18370 (AncyloWKF20_18370) 3962920..3963186 - 267 WP_279315398.1 DUF2285 domain-containing protein -
AncyloWKF20_RS18375 (AncyloWKF20_18375) 3963434..3963682 + 249 WP_279315399.1 helix-turn-helix transcriptional regulator -
AncyloWKF20_RS18380 (AncyloWKF20_18380) 3963766..3964092 - 327 WP_279315400.1 DUF736 domain-containing protein -
AncyloWKF20_RS18385 (AncyloWKF20_18385) 3964722..3965159 - 438 WP_279315401.1 hypothetical protein -
AncyloWKF20_RS18390 (AncyloWKF20_18390) 3965283..3965450 - 168 WP_018387548.1 hypothetical protein -
AncyloWKF20_RS18395 (AncyloWKF20_18395) 3965689..3966111 - 423 WP_279315402.1 type II toxin-antitoxin system VapC family toxin Toxin
AncyloWKF20_RS18400 (AncyloWKF20_18400) 3966108..3966362 - 255 WP_279315403.1 plasmid stabilization protein Antitoxin
AncyloWKF20_RS18405 (AncyloWKF20_18405) 3966447..3967373 - 927 WP_279315404.1 DUF2493 domain-containing protein -
AncyloWKF20_RS18410 (AncyloWKF20_18410) 3967744..3968778 - 1035 WP_279315405.1 toprim domain-containing protein -
AncyloWKF20_RS18415 (AncyloWKF20_18415) 3968848..3970911 - 2064 WP_279315406.1 ParB/Srx family N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3909474..4010202 100728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14958.06 Da        Isoelectric Point: 4.5567

>T276529 WP_279315402.1 NZ_CP121679:c3966111-3965689 [Ancylobacter sp. WKF20]
MILLDTNVISEAMKPTPDDTVRAWLDDQAAETLYLSSVTIAELLYGIGALPAGKRKDRLTEALDGVMELFADRVLPFDVA
AARRYADLAVKARATGKGFPTPDGYIAAIAASRGFAVATRDTSAFDAAGVAVINPWNVER

Download         Length: 423 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.66 Da        Isoelectric Point: 7.2071

>AT276529 WP_279315403.1 NZ_CP121679:c3966362-3966108 [Ancylobacter sp. WKF20]
MPAVTIRNLSEATHRALKVRAAQHGRSTEAEMRDILESAVRPDTRLRLGTELAERTRRLGLTNEDIDALNPARDRTPAEP
MSFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References