Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 416591..417228 Replicon chromosome
Accession NZ_CP121671
Organism Halobacillus naozhouensis strain KCTC 13234

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag P9989_RS02295 Protein ID WP_079526733.1
Coordinates 416878..417228 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag P9989_RS02290 Protein ID WP_079525632.1
Coordinates 416591..416872 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9989_RS02270 (P9989_02265) 412085..412459 + 375 WP_283077228.1 holo-ACP synthase -
P9989_RS02275 (P9989_02270) 412499..414016 + 1518 WP_283077229.1 NAD(P)H-hydrate dehydratase -
P9989_RS02280 (P9989_02275) 414071..415096 + 1026 WP_283077230.1 outer membrane lipoprotein carrier protein LolA -
P9989_RS02285 (P9989_02280) 415268..416434 + 1167 WP_283077231.1 alanine racemase -
P9989_RS02290 (P9989_02285) 416591..416872 + 282 WP_079525632.1 antitoxin Antitoxin
P9989_RS02295 (P9989_02290) 416878..417228 + 351 WP_079526733.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P9989_RS02300 (P9989_02295) 417447..418316 + 870 WP_283077232.1 RsbT co-antagonist protein RsbRA -
P9989_RS02305 (P9989_02300) 418322..418678 + 357 WP_079525635.1 STAS domain-containing protein -
P9989_RS02310 (P9989_02305) 418681..419082 + 402 WP_283077233.1 anti-sigma regulatory factor -
P9989_RS02315 (P9989_02310) 419096..420106 + 1011 WP_283077234.1 PP2C family protein-serine/threonine phosphatase -
P9989_RS02320 (P9989_02315) 420171..420500 + 330 WP_283077235.1 STAS domain-containing protein -
P9989_RS02325 (P9989_02320) 420503..420979 + 477 WP_283077236.1 anti-sigma B factor RsbW -
P9989_RS02330 (P9989_02325) 420951..421730 + 780 WP_283077237.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12897.92 Da        Isoelectric Point: 5.6920

>T276525 WP_079526733.1 NZ_CP121671:416878-417228 [Halobacillus naozhouensis]
VIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAEKYGFERNSVILLEQI
RTIDKQRLTDKITHLDGPMMQQVNESLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10761.24 Da        Isoelectric Point: 4.5908

>AT276525 WP_079525632.1 NZ_CP121671:416591-416872 [Halobacillus naozhouensis]
MVLSDSMQEIVIRIPDSLLSELDGHVQLENSDRSDFMCKATKMYLREEKQRHIRESMRRGYMEMAKINLTIASEAFQAEE
EADHTLEQLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References