Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 9191815..9192407 Replicon chromosome
Accession NZ_CP121668
Organism Bradyrhizobium sp. CB2312

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QA642_RS43810 Protein ID WP_283082352.1
Coordinates 9191815..9192003 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QA642_RS43815 Protein ID WP_283082353.1
Coordinates 9192009..9192407 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA642_RS43790 (QA642_43790) 9188018..9189034 + 1017 WP_283082348.1 TRAP transporter substrate-binding protein -
QA642_RS43795 (QA642_43795) 9189233..9189769 + 537 WP_283082349.1 TRAP transporter small permease -
QA642_RS43800 (QA642_43800) 9189772..9191091 + 1320 WP_283082350.1 TRAP transporter permease -
QA642_RS43805 (QA642_43805) 9191312..9191770 + 459 WP_283082351.1 DUF3237 domain-containing protein -
QA642_RS43810 (QA642_43810) 9191815..9192003 + 189 WP_283082352.1 type II toxin-antitoxin system HicA family toxin Toxin
QA642_RS43815 (QA642_43815) 9192009..9192407 + 399 WP_283082353.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QA642_RS43820 (QA642_43820) 9192597..9193406 + 810 WP_011090568.1 crotonase/enoyl-CoA hydratase family protein -
QA642_RS43825 (QA642_43825) 9193403..9195289 + 1887 WP_283082354.1 feruloyl-CoA synthase -
QA642_RS43830 (QA642_43830) 9195315..9196076 + 762 WP_212426096.1 SDR family NAD(P)-dependent oxidoreductase -
QA642_RS43835 (QA642_43835) 9196162..9196581 + 420 WP_061029942.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6887.98 Da        Isoelectric Point: 11.9537

>T276524 WP_283082352.1 NZ_CP121668:9191815-9192003 [Bradyrhizobium sp. CB2312]
MNSRDIISALQRDGWVQAAQKGSHVQLKHPTKPGRVTVPHPNRDIPLGTLKSIERPSGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14109.97 Da        Isoelectric Point: 4.4085

>AT276524 WP_283082353.1 NZ_CP121668:9192009-9192407 [Bradyrhizobium sp. CB2312]
MRHYIGLIHKDADSDFGVSFPDLPGLVTAGTTLDEARDVAEEALALHLEGMAQDGEAIPAPSSLEQIMSDPENRSGVAIL
VSVKDAQPKIVRVNVTLPGDVLEQIDKYAEAHGYTRSGLLAQAAKKLMTETV

Download         Length: 399 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References