Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 121074..121846 Replicon plasmid pCC283b_2
Accession NZ_CP121637
Organism Rhizobium leguminosarum strain CC283b

Toxin (Protein)


Gene name tacT Uniprot ID A0A2Z4YVU8
Locus tag QA638_RS30715 Protein ID WP_018246328.1
Coordinates 121358..121846 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A7Y3WKI8
Locus tag QA638_RS30710 Protein ID WP_026188748.1
Coordinates 121074..121358 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA638_RS30695 (QA638_30695) 116268..118676 + 2409 WP_018246324.1 ABC transporter permease -
QA638_RS30700 (QA638_30700) 118666..119733 + 1068 WP_018246325.1 lipocalin-like domain-containing protein -
QA638_RS30705 (QA638_30705) 119841..120590 + 750 WP_018246326.1 sulfite exporter TauE/SafE family protein -
QA638_RS30710 (QA638_30710) 121074..121358 + 285 WP_026188748.1 DUF1778 domain-containing protein Antitoxin
QA638_RS30715 (QA638_30715) 121358..121846 + 489 WP_018246328.1 GNAT family N-acetyltransferase Toxin
QA638_RS30720 (QA638_30720) 122142..122354 - 213 WP_245268285.1 hypothetical protein -
QA638_RS30725 (QA638_30725) 122421..122660 + 240 WP_245268286.1 hypothetical protein -
QA638_RS30730 (QA638_30730) 122691..122951 - 261 WP_018246330.1 DUF982 domain-containing protein -
QA638_RS30735 (QA638_30735) 123605..123868 + 264 WP_018246331.1 DUF982 domain-containing protein -
QA638_RS30740 (QA638_30740) 124162..124488 + 327 WP_155256937.1 hypothetical protein -
QA638_RS30745 (QA638_30745) 124525..124737 - 213 WP_018246334.1 hypothetical protein -
QA638_RS30750 (QA638_30750) 125162..125380 + 219 WP_128409058.1 hypothetical protein -
QA638_RS30755 (QA638_30755) 125373..126074 + 702 WP_018246336.1 DUF899 family protein -
QA638_RS30760 (QA638_30760) 126094..126723 - 630 WP_026188749.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..596078 596078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(15-86)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17293.88 Da        Isoelectric Point: 7.9271

>T276472 WP_018246328.1 NZ_CP121637:121358-121846 [Rhizobium leguminosarum]
MLSAPTLLGEAHDLQLFDSGHDSLDEWLRRRARANQVSGASRTYVVCEGERVVGYYCLSSGALAVSDAPGAIRRNMPDPV
PMAVLGRLAIDRNWQGKGIGAALLQDAVLRTGQAAHIMGIRGLLVHAISDEAKAFYEHFGFAASPANPMALVLSLKAQVG
LK

Download         Length: 489 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10687.05 Da        Isoelectric Point: 8.6086

>AT276472 WP_026188748.1 NZ_CP121637:121074-121358 [Rhizobium leguminosarum]
MTSKNATDTHTRAVNLRVREDVRVLIDRAAKAHGKTRSDFMIDASRRAAEDALLDQTLVRVDPDSYKHYLAVLDQPPNSE
GFERLMNAPKPWQP

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z4YVU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3WKI8

References