Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 309490..310106 Replicon plasmid pCC283b_1
Accession NZ_CP121636
Organism Rhizobium leguminosarum strain CC283b

Toxin (Protein)


Gene name vapC Uniprot ID A0A444IHQ6
Locus tag QA638_RS26105 Protein ID WP_018245485.1
Coordinates 309490..309900 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QA638_RS26110 Protein ID WP_245268281.1
Coordinates 309897..310106 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA638_RS26090 (QA638_26090) 305334..306155 + 822 WP_018245488.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
QA638_RS26095 (QA638_26095) 306177..307091 - 915 WP_018245487.1 hydrogen peroxide-inducible genes activator -
QA638_RS26100 (QA638_26100) 307238..309424 + 2187 WP_018245486.1 catalase/peroxidase HPI -
QA638_RS26105 (QA638_26105) 309490..309900 - 411 WP_018245485.1 type II toxin-antitoxin system VapC family toxin Toxin
QA638_RS26110 (QA638_26110) 309897..310106 - 210 WP_245268281.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QA638_RS26115 (QA638_26115) 310287..310844 - 558 WP_018245484.1 DUF3299 domain-containing protein -
QA638_RS26120 (QA638_26120) 311054..311512 - 459 WP_018245483.1 SgcJ/EcaC family oxidoreductase -
QA638_RS26125 (QA638_26125) 311656..312831 + 1176 WP_245268272.1 sensor histidine kinase -
QA638_RS26130 (QA638_26130) 312828..313490 + 663 WP_018245481.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1157213 1157213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14867.09 Da        Isoelectric Point: 6.2317

>T276470 WP_018245485.1 NZ_CP121636:c309900-309490 [Rhizobium leguminosarum]
VITHLIDTNALIALIGRKSEILLKRVIDSDERSIGLSTAVMHELYHGAYKSTKTSYNLETLRLFVADFSVVGFEQEDALA
AGEIRAALAAKGTPIGPYDVLIAAQARTRDLVLVTNNVGVFRRVDGLLVEDWTVGR

Download         Length: 411 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8017.92 Da        Isoelectric Point: 4.4857

>AT276470 WP_245268281.1 NZ_CP121636:c310106-309897 [Rhizobium leguminosarum]
MPKEFRFDVDQVEVTREGDAVILRPRADRGMRWASLHSALERGLSDDFMAEGREQPEGQDRPDLQDLFK

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444IHQ6

Antitoxin

Source ID Structure

References