Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 167100..167902 Replicon plasmid pCC283b_1
Accession NZ_CP121636
Organism Rhizobium leguminosarum strain CC283b

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A444IGY5
Locus tag QA638_RS25475 Protein ID WP_018245608.1
Coordinates 167100..167627 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A7Y3SJF5
Locus tag QA638_RS25480 Protein ID WP_018245607.1
Coordinates 167624..167902 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA638_RS25460 (QA638_25460) 162398..163522 - 1125 WP_018245611.1 DNA repair exonuclease -
QA638_RS25465 (QA638_25465) 163812..165203 - 1392 WP_026188694.1 aldehyde dehydrogenase family protein -
QA638_RS25470 (QA638_25470) 165205..166851 - 1647 WP_018245609.1 acetolactate synthase large subunit -
QA638_RS25475 (QA638_25475) 167100..167627 - 528 WP_018245608.1 GNAT family N-acetyltransferase Toxin
QA638_RS25480 (QA638_25480) 167624..167902 - 279 WP_018245607.1 DUF1778 domain-containing protein Antitoxin
QA638_RS25485 (QA638_25485) 168057..168935 - 879 WP_026188693.1 DUF6030 family protein -
QA638_RS25490 (QA638_25490) 169259..171373 - 2115 WP_018245605.1 carboxy terminal-processing peptidase -
QA638_RS25495 (QA638_25495) 171521..172000 - 480 WP_020493431.1 MEKHLA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1157213 1157213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(12-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18780.78 Da        Isoelectric Point: 9.5510

>T276469 WP_018245608.1 NZ_CP121636:c167627-167100 [Rhizobium leguminosarum]
VTLPVWHEEPIAKSHDRASFDCGDAAMNEFIRRFARQSHEQNAAKTFCAIDKAHPDRILGFYTVAPSAVTHEAVPPKMTR
GLARHEVAGFKLARLATDIKVAGKGLGGQLIAAAALRCLRLASEGGGILLIIDAKSERAAHWYASYGAEPLQGKPLTLVM
PLATFAADLKAKGLL

Download         Length: 528 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10222.91 Da        Isoelectric Point: 9.8602

>AT276469 WP_018245607.1 NZ_CP121636:c167902-167624 [Rhizobium leguminosarum]
MPRTADNKSERYQLRIPPKQKAMIARAAALSNKDMADFILDKIVPEAEAVIQAAEVETVSSRDFIRILDLLERPPKPNAR
LRAAISALPDAL

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444IGY5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3SJF5

References