Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4118110..4118737 Replicon chromosome
Accession NZ_CP121634
Organism Bradyrhizobium sp. CIAT3101

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QA645_RS19430 Protein ID WP_283052314.1
Coordinates 4118549..4118737 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QA645_RS19425 Protein ID WP_283052313.1
Coordinates 4118110..4118502 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA645_RS19400 (QA645_19400) 4113534..4114313 + 780 WP_283052304.1 hypothetical protein -
QA645_RS19405 (QA645_19405) 4114327..4115262 - 936 WP_283052305.1 integrase -
QA645_RS19410 (QA645_19410) 4115408..4115659 - 252 WP_283052307.1 hypothetical protein -
QA645_RS19415 (QA645_19415) 4115827..4116849 - 1023 WP_283052309.1 site-specific integrase -
QA645_RS19420 (QA645_19420) 4116925..4117749 - 825 WP_283052311.1 hypothetical protein -
QA645_RS19425 (QA645_19425) 4118110..4118502 - 393 WP_283052313.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QA645_RS19430 (QA645_19430) 4118549..4118737 - 189 WP_283052314.1 type II toxin-antitoxin system HicA family toxin Toxin
QA645_RS19435 (QA645_19435) 4118991..4119683 + 693 WP_283052316.1 hypothetical protein -
QA645_RS19440 (QA645_19440) 4119752..4120900 + 1149 WP_283052318.1 ImmA/IrrE family metallo-endopeptidase -
QA645_RS19445 (QA645_19445) 4121391..4122179 + 789 WP_283052320.1 hypothetical protein -
QA645_RS19450 (QA645_19450) 4122527..4122847 + 321 WP_283052322.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4112158..4136472 24314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6953.17 Da        Isoelectric Point: 11.0319

>T276466 WP_283052314.1 NZ_CP121634:c4118737-4118549 [Bradyrhizobium sp. CIAT3101]
MKSADLIKALNADGWEQVAQKGSHIQFKHPTKKGRVTVPHPKRDIPIGTLKNIEKQANLKLK

Download         Length: 189 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13749.43 Da        Isoelectric Point: 4.1687

>AT276466 WP_283052313.1 NZ_CP121634:c4118502-4118110 [Bradyrhizobium sp. CIAT3101]
MRYYIALIHKDADSDYGVSFPDLPGVITAGTDLDDARAMAAEALALHLEGMAADGEAVPEPSSLEEIMANTENRDGVAVL
IPAPAEDVKSVRVNITLPADVLSEIDHYAEQHGFTRSGFLAQAAKKAIAA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References