276465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 8211..8799 Replicon plasmid pII_HAB11
Accession NZ_CP121633
Organism Acinetobacter baumannii strain HAB11

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTT06_RS19155 Protein ID WP_000438826.1
Coordinates 8512..8799 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTT06_RS19150 Protein ID WP_001983304.1
Coordinates 8211..8525 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTT06_RS19130 (MTT06_19130) 4038..4409 + 372 WP_000504218.1 hypothetical protein -
MTT06_RS19135 (MTT06_19135) 4409..4582 + 174 WP_001282484.1 hypothetical protein -
MTT06_RS19140 (MTT06_19140) 4905..5366 - 462 WP_000761346.1 DIP1984 family protein -
MTT06_RS19145 (MTT06_19145) 5671..8083 - 2413 Protein_8 TonB-dependent receptor ZnuD2 -
MTT06_RS19150 (MTT06_19150) 8211..8525 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTT06_RS19155 (MTT06_19155) 8512..8799 - 288 WP_000438826.1 BrnT family toxin Toxin
MTT06_RS19160 (MTT06_19160) 9172..9690 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTT06_RS19165 (MTT06_19165) 9879..10022 - 144 WP_001125246.1 hypothetical protein -
MTT06_RS19170 (MTT06_19170) 10042..10617 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTT06_RS19175 (MTT06_19175) 10610..11560 - 951 WP_001205343.1 replication initiation protein RepM -
MTT06_RS19180 (MTT06_19180) 12770..13141 + 372 WP_000504218.1 hypothetical protein -
MTT06_RS19185 (MTT06_19185) 13141..13314 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17462 17462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276465 WP_000438826.1 NZ_CP121633:c8799-8512 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276465 WP_001983304.1 NZ_CP121633:c8525-8211 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References