Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3404..3992 Replicon plasmid pII_JAB144
Accession NZ_CP121628
Organism Acinetobacter baumannii strain JAB144

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS17_RS20410 Protein ID WP_000438826.1
Coordinates 3404..3691 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS17_RS20415 Protein ID WP_001983304.1
Coordinates 3678..3992 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS17_RS20390 (MTS17_20390) 643..1593 + 951 WP_001205343.1 replication initiation protein RepM -
MTS17_RS20395 (MTS17_20395) 1586..2161 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS17_RS20400 (MTS17_20400) 2181..2324 + 144 WP_001125246.1 hypothetical protein -
MTS17_RS20405 (MTS17_20405) 2513..3031 - 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS17_RS20410 (MTS17_20410) 3404..3691 + 288 WP_000438826.1 BrnT family toxin Toxin
MTS17_RS20415 (MTS17_20415) 3678..3992 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS17_RS20420 (MTS17_20420) 4120..6531 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
MTS17_RS20425 (MTS17_20425) 6836..7297 + 462 WP_000761346.1 DIP1984 family protein -
MTS17_RS20430 (MTS17_20430) 7620..7793 - 174 WP_001282484.1 hypothetical protein -
MTS17_RS20435 (MTS17_20435) 7793..8164 - 372 WP_000504218.1 hypothetical protein -
MTS17_RS20440 (MTS17_20440) 8436..8690 - 255 WP_001014303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17459 17459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276458 WP_000438826.1 NZ_CP121628:3404-3691 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276458 WP_001983304.1 NZ_CP121628:3678-3992 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References