276454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 9538..10126 Replicon plasmid pII_JAB117
Accession NZ_CP121613
Organism Acinetobacter baumannii strain JAB117

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS71_RS19320 Protein ID WP_000438826.1
Coordinates 9839..10126 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS71_RS19315 Protein ID WP_001983304.1
Coordinates 9538..9852 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS71_RS19295 (MTS71_19295) 5366..5737 + 372 WP_000504218.1 hypothetical protein -
MTS71_RS19300 (MTS71_19300) 5737..5910 + 174 WP_001282484.1 hypothetical protein -
MTS71_RS19305 (MTS71_19305) 6233..6694 - 462 WP_000761346.1 DIP1984 family protein -
MTS71_RS19310 (MTS71_19310) 6999..9410 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
MTS71_RS19315 (MTS71_19315) 9538..9852 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS71_RS19320 (MTS71_19320) 9839..10126 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS71_RS19325 (MTS71_19325) 10499..11017 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS71_RS19330 (MTS71_19330) 11206..11349 - 144 WP_001125246.1 hypothetical protein -
MTS71_RS19335 (MTS71_19335) 11369..11944 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS71_RS19340 (MTS71_19340) 11937..12887 - 951 WP_001205343.1 replication initiation protein RepM -
MTS71_RS19345 (MTS71_19345) 14097..14468 + 372 WP_000504218.1 hypothetical protein -
MTS71_RS19350 (MTS71_19350) 14468..14641 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17446 17446


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276454 WP_000438826.1 NZ_CP121613:c10126-9839 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276454 WP_001983304.1 NZ_CP121613:c9852-9538 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References