276450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 15473..16061 Replicon plasmid pIII_JAB186
Accession NZ_CP121611
Organism Acinetobacter baumannii strain JAB186

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS34_RS20185 Protein ID WP_000438826.1
Coordinates 15774..16061 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS34_RS20180 Protein ID WP_001983304.1
Coordinates 15473..15787 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS34_RS20155 (MTS34_20155) 10986..11342 + 357 WP_000269902.1 type II toxin-antitoxin system RelE/ParE family toxin -
MTS34_RS20160 (MTS34_20160) 11335..11637 + 303 WP_001140622.1 XRE family transcriptional regulator -
MTS34_RS20165 (MTS34_20165) 11630..11839 + 210 WP_000069473.1 hypothetical protein -
MTS34_RS20170 (MTS34_20170) 12165..12626 - 462 WP_000761346.1 DIP1984 family protein -
MTS34_RS20175 (MTS34_20175) 12931..15345 - 2415 Protein_17 TonB-dependent receptor ZnuD2 -
MTS34_RS20180 (MTS34_20180) 15473..15787 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS34_RS20185 (MTS34_20185) 15774..16061 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS34_RS20190 (MTS34_20190) 16370..17197 + 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
MTS34_RS20195 (MTS34_20195) 17455..17991 - 537 WP_005249161.1 plasmid replication DNA-binding protein -
MTS34_RS20200 (MTS34_20200) 18059..18982 - 924 WP_004282204.1 replication initiation protein RepM -
MTS34_RS20205 (MTS34_20205) 19508..20944 - 1437 WP_039090895.1 MobQ family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / blaOXA-72 - 1..21454 21454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276450 WP_000438826.1 NZ_CP121611:c16061-15774 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276450 WP_001983304.1 NZ_CP121611:c15787-15473 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References