276436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3563..4151 Replicon plasmid pI_RAB11
Accession NZ_CP121587
Organism Acinetobacter baumannii strain RAB11

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS20_RS19410 Protein ID WP_000438826.1
Coordinates 3563..3850 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS20_RS19415 Protein ID WP_001983304.1
Coordinates 3837..4151 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS20_RS19390 (MTS20_19390) 802..1752 + 951 WP_001205343.1 replication initiation protein RepM -
MTS20_RS19395 (MTS20_19395) 1745..2320 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS20_RS19400 (MTS20_19400) 2340..2483 + 144 WP_001125246.1 hypothetical protein -
MTS20_RS19405 (MTS20_19405) 2672..3190 - 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS20_RS19410 (MTS20_19410) 3563..3850 + 288 WP_000438826.1 BrnT family toxin Toxin
MTS20_RS19415 (MTS20_19415) 3837..4151 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS20_RS19420 (MTS20_19420) 4279..6690 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
MTS20_RS19425 (MTS20_19425) 6995..7456 + 462 WP_000761346.1 DIP1984 family protein -
MTS20_RS19430 (MTS20_19430) 7779..7952 - 174 WP_001282484.1 hypothetical protein -
MTS20_RS19435 (MTS20_19435) 7952..8323 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8742 8742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276436 WP_000438826.1 NZ_CP121587:3563-3850 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276436 WP_001983304.1 NZ_CP121587:3837-4151 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References