276433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 11690..12278 Replicon plasmid pII_RAB14
Accession NZ_CP121584
Organism Acinetobacter baumannii strain RAB14

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS22_RS18980 Protein ID WP_000438826.1
Coordinates 11991..12278 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS22_RS18975 Protein ID WP_001983304.1
Coordinates 11690..12004 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS22_RS18955 (MTS22_18955) 7518..7889 + 372 WP_000504218.1 hypothetical protein -
MTS22_RS18960 (MTS22_18960) 7889..8062 + 174 WP_001282484.1 hypothetical protein -
MTS22_RS18965 (MTS22_18965) 8385..8846 - 462 WP_000761346.1 DIP1984 family protein -
MTS22_RS18970 (MTS22_18970) 9151..11562 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
MTS22_RS18975 (MTS22_18975) 11690..12004 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS22_RS18980 (MTS22_18980) 11991..12278 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS22_RS18985 (MTS22_18985) 12651..13169 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS22_RS18990 (MTS22_18990) 13358..13501 - 144 WP_001125246.1 hypothetical protein -
MTS22_RS18995 (MTS22_18995) 13521..14096 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS22_RS19000 (MTS22_19000) 14089..15039 - 951 WP_001205343.1 replication initiation protein RepM -
MTS22_RS19005 (MTS22_19005) 16249..16620 + 372 WP_000504218.1 hypothetical protein -
MTS22_RS19010 (MTS22_19010) 16620..16793 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17460 17460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276433 WP_000438826.1 NZ_CP121584:c12278-11991 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276433 WP_001983304.1 NZ_CP121584:c12004-11690 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References