276429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 169..757 Replicon plasmid pI_RAB53
Accession NZ_CP121580
Organism Acinetobacter baumannii strain RAB53

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS70_RS19285 Protein ID WP_000438826.1
Coordinates 470..757 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS70_RS19280 Protein ID WP_001983304.1
Coordinates 169..483 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS70_RS19280 (MTS70_19280) 169..483 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS70_RS19285 (MTS70_19285) 470..757 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS70_RS19290 (MTS70_19290) 1130..1648 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS70_RS19295 (MTS70_19295) 1837..1980 - 144 WP_001125246.1 hypothetical protein -
MTS70_RS19300 (MTS70_19300) 2000..2575 - 576 WP_243327585.1 plasmid replication DNA-binding protein -
MTS70_RS19305 (MTS70_19305) 2568..3518 - 951 WP_001205343.1 replication initiation protein RepM -
MTS70_RS19310 (MTS70_19310) 4728..5099 + 372 WP_000504218.1 hypothetical protein -
MTS70_RS19315 (MTS70_19315) 5099..5272 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8848 8848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276429 WP_000438826.1 NZ_CP121580:c757-470 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276429 WP_001983304.1 NZ_CP121580:c483-169 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References