276427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2179..2767 Replicon plasmid pI_RAB55
Accession NZ_CP121578
Organism Acinetobacter baumannii strain RAB55

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS49_RS19325 Protein ID WP_000438826.1
Coordinates 2480..2767 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS49_RS19320 Protein ID WP_001983304.1
Coordinates 2179..2493 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS49_RS19320 (MTS49_19320) 2179..2493 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS49_RS19325 (MTS49_19325) 2480..2767 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS49_RS19330 (MTS49_19330) 3140..3658 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS49_RS19335 (MTS49_19335) 3847..3990 - 144 WP_001125246.1 hypothetical protein -
MTS49_RS19340 (MTS49_19340) 4010..4585 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS49_RS19345 (MTS49_19345) 4578..5528 - 951 WP_001205343.1 replication initiation protein RepM -
MTS49_RS19350 (MTS49_19350) 6738..7109 + 372 WP_000504218.1 hypothetical protein -
MTS49_RS19355 (MTS49_19355) 7109..7282 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8733 8733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276427 WP_000438826.1 NZ_CP121578:c2767-2480 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276427 WP_001983304.1 NZ_CP121578:c2493-2179 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References