276424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 10300..10888 Replicon plasmid pII_RAB73
Accession NZ_CP121569
Organism Acinetobacter baumannii strain RAB73

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS81_RS19425 Protein ID WP_000438826.1
Coordinates 10601..10888 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS81_RS19420 Protein ID WP_001983304.1
Coordinates 10300..10614 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS81_RS19400 (MTS81_19400) 6128..6499 + 372 WP_000504218.1 hypothetical protein -
MTS81_RS19405 (MTS81_19405) 6499..6672 + 174 WP_001282484.1 hypothetical protein -
MTS81_RS19410 (MTS81_19410) 6995..7456 - 462 WP_000761346.1 DIP1984 family protein -
MTS81_RS19415 (MTS81_19415) 7761..10172 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
MTS81_RS19420 (MTS81_19420) 10300..10614 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS81_RS19425 (MTS81_19425) 10601..10888 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS81_RS19430 (MTS81_19430) 11261..11779 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS81_RS19435 (MTS81_19435) 11968..12111 - 144 WP_001125246.1 hypothetical protein -
MTS81_RS19440 (MTS81_19440) 12131..12706 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS81_RS19445 (MTS81_19445) 12699..13649 - 951 WP_001205343.1 replication initiation protein RepM -
MTS81_RS19450 (MTS81_19450) 14837..15208 + 372 WP_000504218.1 hypothetical protein -
MTS81_RS19455 (MTS81_19455) 15208..15381 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17436 17436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276424 WP_000438826.1 NZ_CP121569:c10888-10601 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276424 WP_001983304.1 NZ_CP121569:c10614-10300 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References