276423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1569..2157 Replicon plasmid pII_RAB73
Accession NZ_CP121569
Organism Acinetobacter baumannii strain RAB73

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS81_RS19375 Protein ID WP_000438826.1
Coordinates 1870..2157 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS81_RS19370 Protein ID WP_001983304.1
Coordinates 1569..1883 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS81_RS19370 (MTS81_19370) 1569..1883 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS81_RS19375 (MTS81_19375) 1870..2157 - 288 WP_000438826.1 BrnT family toxin Toxin
MTS81_RS19380 (MTS81_19380) 2530..3048 + 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS81_RS19385 (MTS81_19385) 3237..3380 - 144 WP_001125246.1 hypothetical protein -
MTS81_RS19390 (MTS81_19390) 3400..3975 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS81_RS19395 (MTS81_19395) 3968..4918 - 951 WP_001205343.1 replication initiation protein RepM -
MTS81_RS19400 (MTS81_19400) 6128..6499 + 372 WP_000504218.1 hypothetical protein -
MTS81_RS19405 (MTS81_19405) 6499..6672 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17436 17436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276423 WP_000438826.1 NZ_CP121569:c2157-1870 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276423 WP_001983304.1 NZ_CP121569:c1883-1569 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References