Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1017..1605 Replicon plasmid pI_RAB97
Accession NZ_CP121562
Organism Acinetobacter baumannii strain RAB97

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS88_RS20075 Protein ID WP_000438826.1
Coordinates 1017..1304 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS88_RS20080 Protein ID WP_001983304.1
Coordinates 1291..1605 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS88_RS20070 (MTS88_20070) 126..644 - 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS88_RS20075 (MTS88_20075) 1017..1304 + 288 WP_000438826.1 BrnT family toxin Toxin
MTS88_RS20080 (MTS88_20080) 1291..1605 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS88_RS20085 (MTS88_20085) 1733..2437 + 705 Protein_3 TonB-dependent receptor ZnuD2 -
MTS88_RS20090 (MTS88_20090) 2463..3392 + 930 WP_001091151.1 IS5-like element ISAba10 family transposase -
MTS88_RS20095 (MTS88_20095) 3446..5176 + 1731 Protein_5 TonB-dependent receptor ZnuD2 -
MTS88_RS20100 (MTS88_20100) 5481..5942 + 462 WP_000761346.1 DIP1984 family protein -
MTS88_RS20105 (MTS88_20105) 6265..6438 - 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9763 9763
- flank IS/Tn - - 2463..3392 929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276417 WP_000438826.1 NZ_CP121562:1017-1304 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276417 WP_001983304.1 NZ_CP121562:1291-1605 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References